A review of the literature on the use of Prometrium in women with premenstrual syndrome, with endocrine-related infertility, to support implanted embryos and preservation of pregnancy in the first trimester is presented; in the implementation of in vitro fertilization in the program of donation of eggs, as well as in vitro fertilization and the stimulation of cycles by analogues of gonadotropin-releasing hormone. The vaginal route of administration of Prometrium is recommended for short-term courses of therapy (only in the first trimester of pregnancy) to support the luteal phase in spontaneous or induced menstrual cycles in infertility associated with impaired function of the corpus luteum (disovulatory cycles); to support the luteal phase when stimulating cycles for in vitro fertilization; replacement therapy in women with nonfunctioning ovaries (in the oocyte donation program); with the threat of termination of pregnancy or in order to prevent habitual abortions arising in connection with dysfunction of the corpus luteum.
Is Utrogestan the same as Prometrium?
Premenstrual syndrome is a complex of pronounced changes in the state of a woman that occur in the second half of the menstrual cycle and disappear when menstruation occurs. In its pathogenesis, ovarian dysfunction is of significant importance, which is manifested by a decrease in hormonal activity of the corpus luteum and the development of relative hyperestrogenism. Prometrium (Utrogestan) is a brand medication, not generic. In studies L. Dennerstein and co-authors (1985) found that the use of Prometrium in the recommended doses (200–300 mg per day, in the second half of the menstrual cycle) contributed to an increase in the level of progesterone in the blood plasma, achieving an anti-estrogenic effect sufficient in particular, engorgement and tenderness of the mammary glands, vasomotor and neuropsychiatric disorders. Regarding the latter, this study found that ingesting micronized progesterone (Prometrium) has a sedative effect.
Buy Prometrium online
The sedative effect of the drug distinguishes it from many synthetic progestins, which cause disturbances from the emotional sphere. The sedative effect of Prometrium is similar to physiological, whereas many synthetic progestins can cause mood changes. The most optimal tranquilizing effect of the drug is noted when prescribed at a dose of 200 mg at bedtime. In addition, the previously described antialdosterone activity of Prometrium has been confirmed. Progesterone is an aldosterone antagonist and helps to increase diuresis and sodium excretion in the urine. Synthetic progestins do not have sufficient anti-aldosterone activity. Unlike 19-nortestosterone or 17-hydroxyprogesterone derivatives, Prometrium is a physiological inhibitor of aldosterone. A dose of 200 mg of Prometrium is equivalent to a dose of 25-50 mg of spironolactone as an aldosterone inhibitor.
How much does prometrium cost without insurance?
In a randomized, single-center, placebo-controlled study, the efficacy and safety of oral intake of micronized progesterone in two doses (200 and 300 mg 1 time per day for 10 days) were compared in menstrual induction in patients with secondary amenorrhea. Prometrium cost without insurance is around $200. It was found that menstruation occurred in 5 (24%) of 21 patients who received placebo, 10 (53%) of 19 and 18 (90%) of 20 patients who received micronized progesterone at a dose of 200 and 300 mg / day, respectively. Both doses of micronized progesterone could induce the menstrual cycle in patients with secondary amenorrhea, however, statistically significant differences compared with the placebo effect were observed only when 300 mg of micronized progesterone were taken.
Should prometrium be taken with food?
Oral administration of micronized progesterone in a dose of 300 mg 1 time per day before going to bed for 10 days facilitated the induction of menstruation in patients with secondary amenorrhea and normal production of endogenous estrogen. Do not take Prometrium with food as this may affect the way Prometrium works.Another study was conducted with the participation of 80 women in the premenopausal period. Patients were randomly assigned to groups. In one group, patients from the 15th to the 25th day of the menstrual cycle were prescribed 15 mg / day of norethisterone, and in the other group, 300 mg / day of micronized progesterone was administered orally. Diagnostic curettage of the uterus is performed in all patients. Cystic glandular hyperplasia, proliferating endometrium, or incomplete maturation were detected in 40, 30, and 9 cases, respectively. In the study of biopsy specimens taken from patients of both groups at 6 months, no endometrial hyperplastic changes were found.
Prometrium benefits and usefulness
The study is most important in the study of the use of progesterone in the postmenopausal period in women who are constantly receiving estrogen. During this multicenter, prospective, placebo-controlled study, which lasted 3 years, compared the effectiveness of micronized progesterone in preventing endometrial hyperplasia compared with placebo and two different medroxyprogesterone regimens. Women who received only estrogen had a higher risk of developing simple, mixed, or atypical endometrial hyperplasia than women who received placebo. The incidence of hyperplasia was the same in women who received one of the three estrogens and progestin according to the scheme, and those who received placebo. The effectiveness of micronized progesterone (at a dose of 200 mg 1 time per day before bedtime) in preventing the development of endometrial hyperplastic changes associated with estrogen therapy was comparable in treatment. In a study of endometrial biopsies taken 24 weeks after treatment, none of the women of both groups treated with micronized progesterone in combination with one of the estrogens, no endometrial hyperplasia was detected.
What is Prometrium 100mg used for?
In an open study, endometrial biopsies were examined for 5 years and / or hysteroscopic monitoring was performed on 157 women who regularly took estradiol (transdermally) in combination with Prometrium for 21 days with a 28-day cycle in women who want to resume menstrual-like bleeding. With Prometrium Prem (300 mg / day), for 10 days, starting from the 11th day of estradiol use, menstrual-like bleeding was more common after treatment was discontinued and more secretory endometrial changes were detected histologically. Prometrium is used to cause menstrual periods in women who have not yet reached menopause but are not having periods due to a lack of progesterone in the body. This medicine is also used to prevent overgrowth in the lining of the uterus in postmenopausal women who are receiving estrogen hormone replacement therapy. The administration of micronized progesterone (200 mg / day) for 14 days starting from the 7th day of estradiol use more often caused subatrophic changes in the endometrium and amenorrhea. In patients of both groups, there was no development of endometrial hyperplasia and carcinoma. According to the study, endometrial secretory changes and bleeding after discontinuation of treatment aimed at preventing hyperplasia were almost equally often observed with the induction of amenorrhea during the development of endometrial subatrophy.
What are the side effects of taking Prometrium?
A similar endometrial reaction was observed in women who received transdermal estradiol Prometrium at a dose of 100 mg / day for 25 days. Side effects: drowsiness, dizziness; breast pain; mood changes; headache; constipation, diarrhea, heartburn; bloating, swelling in your hands or feet; joint pain. In a randomized study, 40 postmenopausal women underwent replacement therapy — estradiol was administered transdermally on days 1–25 of the 28-day cycle and compared the effect of using micronized progesterone (200 mg / day) and MPA (10 mg / day) administered from 14 th and on the 25th day of the use of estradiol. The course of treatment consisted of 13 cycles. In the study of endometrial biopsies obtained before and after treatment, hyperplasia was not detected. According to data from daily surveys, in women who received micronized progesterone, the bleeding was less pronounced and less prolonged than in those who took MPA.
Where to Buy Prometrium? The required progestin drug should have a minimal side effect on metabolic processes. Data from a randomized controlled study of the efficacy of vaginal administration of Prometrium and injected intramuscular progesterone indicate that patients receiving progesterone (vaginal route of administration) had a higher implantation rate and significantly lower percentage of abortions (9.8%) than in m progesterone (29.4%). It is usually taken once a day in the evening or at bedtime. You will probably take progesterone on a rotating schedule that alternates 10 to 12 days when you take progesterone with 16 to 18 days when you do not take the medication. Your doctor will tell you exactly when to take progesterone. Another study compared the morphological characteristics of the endometrium with prolonged use without the support of the luteal phase by means of hCG, progesterone, administered intramuscularly or vaginally. The delay in maturation of the endometrium was more often noted in patients who did not have support for the luteal phase. In addition, nonsynchronous maturation of the endometrium was significantly more frequently noted with the support of the luteal phase by means of hCG or progesterone, administered intramuscularly, than by vaginal administration of progesterone. Two recent studies have confirmed that with vaginal administration of Prometrium, better results can be achieved than with oral administration.